More importantly, MAFB knockdown led to a significant downregulation of the gene sets that define the pathogenic SPP1+ MØ (GSE145926) (49), MoAM3 (GSE155249) (39), or CD163+/LGMN+ MØ (accession number EGAS00001005634) (48) subsets in severe COVID-19 (Figure 1D and Supplemental Figure 1A). Here, SPP1 is linked to COVID-19.