Next, we determined the gene signature of M-MØ from a patient with multicentric carpotarsal osteolysis (MCTO, MCTO M-MØ) (GSE155883) (20) (Figure 1E and Supplemental Figure 1G), a pathology caused by mutations that enhance MAFB protein stability and expression (51) (Supplemental Figure 1H). The gene discussed is MAFB; the disease is multicentric carpo-tarsal osteolysis with or without nephropathy.