MAFB and viral infectious disease: After confirming the diminished expression of MAFB both before and 30 hours after viral infection (Figure 5B), analysis of the transcriptome of the resulting ΔMAFB M-MØ SARS and ΔMAFB GM-MØ SARS revealed that MAFB silencing not only impaired the expression of MAFB-dependent genes, CHIR99021-upregulated genes, and the 75-gene set (Figure 5C and Supplemental Figure 4A), as expected, but it drastically affected the expression of SARS-CoV-2–regulated genes in M-MØ and GM-MØ (Figure 5D).