SPP1 and COVID-19: MCTO M-MØ not only showed a positive enrichment of MAFB-dependent genes (Supplemental Figure 1I) but exhibited a high overrepresentation of the gene sets that define the profibrotic MoAM3 (39), SPP1+ (49), and CD163+/LGMN+ (48) macrophage subsets from lungs of patients with severe COVID-19 (Figure 1F).