CXCL2 and severe acute respiratory syndrome: However, a considerable number of genes was identified whose expression was MAFB-dependent exclusively in SARS-CoV-2–exposed macrophages (ΔMAFB M-MØ SARS and/or ΔMAFB GM-MØ SARS) (Supplemental Figure 4, B and C), including genes encoding chemokines with profibrotic and monocyte-recruiting functions (e.g., CCL3, CCL13, CCL18) or neutrophil-attracting activity (e.g., CXCL2, CXCL5) (Figure 6A and Supplemental Figure 4D).