Indeed, the 75-gene set included genes shared by the various pathogenic monocyte-derived macrophage clusters identified in severe COVID-19 (39, 48–50), like CCL2, CD163, CMKLR1, CSF1R, LGMN, MAF, MARCKS, and OLFML2B, and whose MAFB-dependent expression was confirmed on a validation set of ΔMAFB M-MØ samples (Figure 3G) and also at the protein level (Figure 3H). Here, OLFML2B is linked to COVID-19.