Gene-edited (t;411) cells, (t;911) ALL cells (4), and patient KMT2A-AFF1 BCP-ALL grouped together more than other leukemia subsets (gene-edited KMT2A-MLLT3 AML, MPAL, and KMT2A-AFF1 human cell lines), consistent with their phenotypic similarities. This evidence concerns the gene MLLT3 and acute lymphoblastic leukemia.