CISH and Autoimmunity: For example, Cytokine signaling suppressor 3 (SOCS3), SOCS proteins are expressed by immune cells and central nervous system (CNS) cells and have the ability to affect the immune processes of the CNS, such as participating in the production of inflammatory cytokines and chemokines, activation of microglia, macrophages and astrocytes, immune cell infiltration and autoimmunity [28].