Primary Sjögren's syndrome (pSS) is a complex autoimmune disorder characterized by the activation of type I and II interferon (IFN) responses in the salivary gland (SG) and peripheral blood (PB) (Emamian et al, 2009; Hall et al, 2012; Bodewes et al, 2018, 2019. Here, IFNA1 is linked to peeling skin syndrome.