To address this, we first evaluated by flow cytometry the frequencies of different circulating myeloid cell subsets including Lineage− CD14− CD11c− HLADR+ CD123+ pDCs, and Lineage− CD14− CD11c− HLADR+ cDC2 (CD1c+) and cDC1 (CD141+) in the PB from pSS individuals recruited to our study and compared with patterns from HD (Appendix Fig S3A). The gene discussed is ITGAX; the disease is Huntington disease.