The tumor-normal NOP tests found no PGVs in BRCA1, BRCA2, MLH1, and MSH2 in patients under 20 years of age, whereas the tumor-only F1CDx tests showed nine cases of BRCA1 or BRCA2 and seven cases of MLH1 or MSH2 with pathogenic variants. The gene discussed is MSH2; the disease is neoplasm.