In contrast, in NOP, BRCA2 germline variants were most common in pancreatic cancer, followed by breast, ovarian (including peritoneal), and prostate cancers, whereas BRCA2 somatic variants were not found in ovarian cancer, were increased in gastrointestinal and prostate cancers, and were less common in breast and ovarian cancers than germline variants. The gene discussed is BRCA2; the disease is prostate cancer.