BRCA1 and cancer: A recent report by Momozawa and colleagues (25) showed that PGVs in BRCA1 and/or BRCA2 were associated with an increased risk of the biliary tract, gastric, and esophageal cancers, suggesting that the range of cancer types associated with PGVs in BRCA1 and BRCA2 was broader than that previously determined from the analyses of cohorts of largely European ancestry.