INS and metabolic disease: Stromal cell-derived factor 2 like 1 (Sdf2l1) is important in liver metabolism, and in a study on mice, Sasako and colleagues found that in the liver, impaired induction of Sdf2l1 resulted in sustained endoplasmic reticulum (ER) stress, leading to insulin resistance and increased triglyceride contents, even with a normal-chow diet, indicating that dysregulation of ER stress by suppression of Sdf2l1 is a causal factor of metabolic disorders (Sasako et al., 2019).