Additionally, it has been demonstrated in NSCLC cell lines that estrogen can induce downregulation of EGFR expression in tumor cells (20), and this finding was also verified in mouse experiments that the administration of exogenous estrogen to male mice significantly inhibited the growth of lung cancer and attenuated NF-κB-driven immunosuppression (21). This evidence concerns the gene NFKB1 and non-small cell lung carcinoma.