These results indicate that Pc infection in combination with Gem treatment significantly inhibits tumor growth and metastasis, and prolongs the survival of lung cancer-bearing mice partially through inhibiting EMT of tumor cells that is possibly related to the blockade of CXCR2/TGF-β-mediated PI3K/Akt/GSK-3β/Snail signaling pathway. The gene discussed is CXCR2; the disease is lung cancer.