Results obtained in this study are consistent with these reports, since we found that lung adenocarcinoma cell lines harboring wild-type EGFR exhibited distinct sensitivity to CDDP that could be related to alterations in TP53. The A549 cell line, which expresses TP53 WT, showed high sensitivity to CDDP compared to cell lines H1299 and H1573 that exhibit TP53 alterations (null and c.743G>T, respectively). The gene discussed is EGFR; the disease is lung adenocarcinoma.