TFPI2 and pancreatic adenocarcinoma: Furthermore, FTO inhibited the expression of TFPI-2 mRNA through the m6A reader YTHDF1, leading to the down-regulation of TFPI-2 expression and ultimately promoting the proliferation, colony formation, sphere formation, migration, and invasion of PAAD cells, as well as tumor growth in vivo (51) (Figures 2G, H).