Furthermore, FTO inhibited the expression of TFPI-2 mRNA through the m6A reader YTHDF1, leading to the down-regulation of TFPI-2 expression and ultimately promoting the proliferation, colony formation, sphere formation, migration, and invasion of PAAD cells, as well as tumor growth in vivo (51) (Figures 2G, H). The gene discussed is FTO; the disease is neoplasm.