Patients achieving complete T2D remission (69% of the sample) had higher initial C-peptide 1.83 ± 0.95 vs 0.67 ± 0.26 nmol/L (P=0.040), higher postprandial serum C-peptide to plasma glucose concentration ratio 1.28 ± 0.93 vs 0.30 ± 0.22 (P=0.015), lower T2D duration 9.6 ± 8.3 vs 16.2 ± 8.4 years (P=0.216), but similar proportion of insulin treatment compared to non-remitters. This evidence concerns the gene INS and type 2 diabetes mellitus.