An increase in serum proinflammatory cytokines, which include interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha), which are found to create modifications to the metabolism of lipids leading to high levels of lipids have been associated with periodontitis-induced bacteremia/endotoxemia. Here, IL1B is linked to serum lipopolysaccharide activity.