Specifically, the preliminary results of IVW revealed negative causal effect of two cytokines on sepsis, including RANTES (regulated on activation, normal T-cell expressed and secreted (CCL5)) [OR = 0.920, 95% CI: 0.849-0.997, P = 0.041] and basic fibroblast growth factor (basic-FGF) [OR = 0.869, 95% CI: 0.766-0.986, P = 0.029], and positive causal effect of beta-nerve growth factor (β-NGF) and sepsis [OR = 1.120, 95% CI: 1.037-1.211, P = 0.004] (Table 1 and Figure 2). This evidence concerns the gene FGF2 and Sepsis.