CD8A and chronic obstructive pulmonary disease: CD8 immunostainings were also increased in moderate and severe COPD core groups as compared with controls, although to a lower extent (COPD, moderate cores vs controls, log2FC = 1.84, p<0.001; COPD, severe cores vs controls, log2FC = 1.07, p=0.01) (Figures 4B, C).