CD8A and neoplasm: Besides, the vascular normalization effect is associated with more efficient lymphocyte priming by antigen-presenting cells, TAM polarization to an M1-like phenotype, and accumulation of activated, IFN-γ expressing CD8+ T cells within the perivascular space (29, 30) M1-like TAMs are generally considered to be tumor-killing macrophages, primarily anti-tumor and immune-promoting (12) (Figure 2).