Tumor-derived exosomes foster a protumor N2 phenotype in several types of cancer, such as gastric cancer, where exomes carrying HMGB1 induced the N2 phenotype by TLR4/NF-κB signaling (56) or CRC, where CRC stem cell-derived exosomes enhances neutrophils survival through the transfer of triphosphate RNAs that stimulates IL-1β expression (57). Here, HMGB1 is linked to colorectal carcinoma.