Often, these molecules exhibit similarities to those previously described for tumor-derived exosomes, including proinflammatory proteins and checkpoint receptor ligands, such as the proinflammatory proteins S100A8 and S100A9 in myeloid-derived suppressor cell (MDSC)-derived exosomes or PDL1 in T cell-derived exosomes (41, 42). The gene discussed is CD274; the disease is neoplasm.