CD274 and lung cancer: Whereas DNT cells from healthy donors could kill lung cancer cells, this activity was reduced by MPE: MPE supernatant-derived exosomes, exhibiting immune checkpoint molecules like CEACAM1 and PDL1, have been observed to inhibit the cytotoxicity of DNT cells, at least partially, through CEACAM1/TIM3 and PDL1/PD1 pathways.