C3 and infection: Both anaphylatoxins, C3a and C5a, have been confirmed as important drivers of NLRP3 inflammasome activation (19), and recently, exacerbating intracellular C3 mobilization as well as anaphylatoxin secretion from non-immune HAE cells following infection with SARS-CoV-2 wild type, Beta and Delta variants were described (9, 10, 15, 20).