AKT1 and infection: Overexpression of Akt in the midgut also results in abnormal mitochondria morphology and significantly reduced number of mitochondria in the midgut (122), with mitochondrial dysfunction evident in reduced activity of Mitochondrial Complexes I, II-II, and V. Additionally, Akt-overexpression in the fat body of mosquitos systemically infected with E. coli or Bacillus subtilis led to higher induction of antimicrobial peptides and higher survivorship of infection (118).