The cGAS-STING pathway exacerbates cerebral ischemic injury has been confirmed through experiments using si-cGAS inhibition of microglial M1 polarization in a middle cerebral artery occlusion (MCAO) mouse model, resulting in the downregulation of the M1/M2 ratio and attenuation of neuroinflammation in ischemic stroke by suppressing the shift in microglia phenotype (23). The gene discussed is CGAS; the disease is ischemic stroke.