Additional mechanisms proposed to explain the pro-migratory and pro-invasive effects of eNAMPT are 1) the induction of matrix-degrading enzymes in cancer cells, such as MMP-2 and -9 gelatinases (214, 218, 221, 222, 226, 227, 232) and 2) the stimulation of angiogenesis by inducing pro-angiogenic factors in endothelial cells (81) and cancer cells (222). The gene discussed is MMP2; the disease is cancer.