The ALT-100 antibody reduced total BAL cell and BAL PMN counts, the lung tissue wet/dry weight ratio, the plasma levels of IL-6, IL-1Ra, and Ang-2, and BAL protein and lung tissue albumin levels in LPS/VILI-challenged pigs (P < 0.05). In addition, ALT-100 attenuated acute kidney injury in LPS/VILI-challenged pigs, as evidenced by reductions in histopathologic score, caspase-3 cleavage staining levels, and plasma lipocalin levels (P < 0.05). Here, CASP3 is linked to acute kidney injury.