Serum eNAMPT levels were higher in ALI patients than in control individuals (P < 0.001). A negative correlation between eNAMPT levels and survival rate of ALI patients was found (P = 0.002). In addition, eNAMPT levels positively correlated with those of IL-6 (ρ = 0.584, P < 0.001), IL-8 (ρ = 0.313, P = 0.001), IL-10 (ρ = 0.319, P = 0.001), and MCP-1 (ρ = 0.242, P = 0.011). Here, CXCL8 is linked to acute respiratory distress syndrome.