IL6 and acute respiratory distress syndrome: Both the anti-NAMPT pAb and ALT-100 reduced LPS-induced histological evidence of inflammation and injury, as well as BAL protein content and BAL PMN counts, in preclinical “one-hit” and “two-hit” ARDS mouse models (P < 0.05). In addition, ALT-100 decreased plasma IL-6 levels in mice exposed to “one-hit” or “two-hit” challenge (P < 0.05).