T2DM patients had higher levels of serum eNAMPT than controls (P = 0.001). In the T2DM group, a positive correlation was found between eNAMPT levels and IL-6 (r = 0.47, P < 0.0001), TNF-α (r = 0.62, P < 0.0001), CRP (r = 0.40, P < 0.002), WC (r = 0.38, P = 0.001), BMI (r = 0.40, P = 0.008), and IR (r = 0.48, P = 0.001). The gene discussed is TNF; the disease is type 2 diabetes mellitus.