In addition, key regulators in ferroptosis includingSLC7A11,GPX4, andAIFM2were dysregulated in a variety of tumors (such as LUSC) and were candidate prognostic biomarkers for many types of cancer and could be used to assess the infiltration of immune cells in immune cells in tumor tissues.35Nevertheless, few studies have reported the ferroptosis-related genes that are associated with the prognosis for LUSC patients. This evidence concerns the gene GPX4 and cancer.