In this review, the PubMed, China National Knowledge Infrastructure (CNKI), and Web of Science databases were searched until to August 2023 using the keywords “curcumin,” “ischemic stroke” OR “stroke,” and “NLRP3” OR “NLRP3 inflammasome” to demonstrate the pathways network between NLRP3 and curcumin therapy in ischemic stroke. The gene discussed is NLRP3; the disease is stroke disorder.