The elevation of p-Akt/p-mTOR and the reduction of IL-1β, TLR4, p-38, and p-p38 levels have also been observed after curcumin administration in ischemic stroke and were concomitant with curtailed LC-3-II and NLRP3 markers (Huang et al., 2018). The gene discussed is NLRP3; the disease is ischemic stroke.