In lupus nephritis (LN), gut‐derived group 3 innate lymphoid cells (ILC3s) migrate from the small intestine to the kidney via CXCR6/CXCL16 axis, and contribute to the progression of LN, including spleen and lymph node enlargement, antibody production and renal injury. Here, CXCL16 is linked to lobular neoplasia.