CXCR6 and lobular neoplasia: By coincidence, CXCR6's corresponding chemokine ligand, CXCL16, has been reported to be increased in the serum and urine of LN patients and in the kidneys of LN murine models including MRL/lpr mice,[21] thus illustrating the corresponding driving force for the axial migration of ILC3s from the intestine to the kidney.