Besides, it was reported that splenic ILC3s promoted MZB cells to produce IgG3 antibodies, which were characteristic of T cell‐independent extrafollicular responses.[39a] In lupus, plasma cells can arise through both germinal center or extrafollicular pathways.[41] It would be interesting to identify which subclass of autoantibodies and pathways of B cell response were enhanced by ILC3s in LN. The gene discussed is IGHG3; the disease is systemic lupus erythematosus.