More recently, a pH‐responsive nanoplatform comprised of an amphiphilic cationic lipid G0‐C14 and a pH‐liable copolymer (Meo‐PEG‐Dlinkm‐PLGA) containing MAA unit was prepared for PTEN mRNA delivery, which could block the activity of PI3K/Akt signaling pathway through PTEN expression and lead to the reversal of trastuzumab resistance in breast cancer treatment.[133]. The gene discussed is PTEN; the disease is breast cancer.