CEACAM5 and neoplasm: MART-1, glycoprotein 100 (gp100), tyrosinase related protein-1 (TRP-1), Her2/neu, and carcinoembryonic antigen (CEA) are also examples of trans-membrane proteins as trimeric autotransporter adhesins (TAAs) that spontaneously associate with Exos, and then activate particular anti-tumor T cell responses.