TLR4 and COVID-19: This revealed a total of 88 unique drugs that target TLR4 (either singularly or as part of a combination therapy), including 8 in development for acute COVID-19, the most advanced of which (Paridiprubart, Edesa Biotech Inc) is currently being evaluated in a Phase 3 study in hospitalized COVID-19 patients with Acute Respiratory Distress Syndrome (ARDS) [72].