Firstly, we have only demonstrated that sEH could alleviate the COPD airway inflammatory response through the IRE1α/JNK/AP-1 signaling pathway, but further blocking assays of the IRE1α/JNK/AP-1 signaling pathway in mice are needed to demonstrate the role of the IRE1α/JNK/AP-1 signaling pathway in attenuating the COPD airway inflammatory response. This evidence concerns the gene ERN1 and chronic obstructive pulmonary disease.