Herein, we solely focused on studying the effects of TFPI2 overexpression or knockdown on cardiac remodelling and function recovery 3 weeks after infarction, whereas their effects on long-term prognosis remain to be determined; (2) whether TFPI2 downregulation in the infarcted heart is related to DNA hypermethylation of the TFPI2 promoter under diabetic conditions and the underlying molecular mechanisms remain to be determined; and (3) the molecular mechanism of TFPI2 regulating PPARγ expression remains to be explored. The gene discussed is TFPI2; the disease is infarction.