The results of IHC of CD8+ in animal transplanted tumor samples indicate that mice administered with M2/sh-1592#2-Exos or M2-Exos + Annexin V exhibited considerably elevated levels of the protein in comparison to mice administered with M2/sh-NC-Exos or M2-Exos alone (Figs. 3F–G). The gene discussed is ANXA5; the disease is neoplasm.