HK2 and cancer: Akt1 and p-Akt1 were key elements of PI3K/Akt signaling pathways that regulate cellular processes, including proliferation, differentiation, migration and survival, the HK2 (the member of hexokinases, Associated with malignant tumor growth and distant metastasis) and AKT1 (p-AKT1) may regulated in the same networks in cervical cancer cells and synergistically promoted malignant growth and distant metastasis during the development of cervical cancer [41].