CXCR4 and neoplasm: Invasion and metastasis of tumor cells through the bloodstream and lymphatic vessels were key steps in the progression of cervical cancer, CCR7 was implicated in mediating lymphocyte trafficking and spreading to lymph nodes, expression of CCR7, CXCR4, VEGF-C and VEGF-D may have a synergistic effect on the malignant development of cervical cancer and lymph node metastasis [40].