CTNNB1 and cervical cancer: According to the results of patient B15 (Fig. 3B), CTNNB1 related to the development of cervical cancer was found before treatment (Table 3); ATF3 and GPX3 related to cervical cancer progression were found after treatment (Table 4), that indicated the HPV integration profiling changes along the course of treatment and the patient needs further follow-up examinations.