GDF15 and neoplasm: We also identified proximal and distal enhancers that are linked to ASAP2 upregulation in primary PDAC cells, which promotes cell migration and tumour growth in vitro and in PDAC xenograft models27, as well as identifying genetic drivers (TP53 mutant in BRCA) that influence the chromatin accessibility of genes that are involved in cell motility, invasion and proliferation (GDF15 and FGD3).