Examples of tissue-specific regulons include FOXA1 and GATA3 in BRCA non-basal cancer, KLF4 and FOSL1 in CESC and HNSCC, HNF1A and KLF9 in ccRCC, and HNF4G and GATA6 in CRC and PDAC. The gene discussed is KLF4; the disease is head and neck squamous cell carcinoma.