Cancer-type-specific DACRs included HOX TF HOXA4 in GBM, an unfavourable prognostic factor in glioma19, the clinically significant marker FGF19 in BRCA (of non-basal subtypes)20 and hypoxia-inducible factor 3 EGLN3, a known pathological marker of ccRCC21. The gene discussed is TF; the disease is cancer.