E2F8 and glioblastoma: By contrast, the tissue-specific regulons E2F8 (CRC) and BACH2 (GBM) had higher scores in the respective CNCs (Supplementary Table 4c) and were linked to better survival in the TCGA-CRC and TCGA-GBM cohorts, respectively (Extended Data Fig. 10c and Supplementary Table 9b,d).