Mice bearing orthotopic xenografts of NTRK2-KO DIPG in the brainstem or NTRK2-KO paediatric cortical glioblastoma in the frontal cortex exhibited a marked increase in overall survival compared with littermate controls xenografted with NTRK2 wild-type cells (Fig. 1f and Extended Data Fig. 1i,j). This evidence concerns the gene NTRK2 and glioblastoma.