COL18A1 and hereditary angioedema: The 2 patients with HAE-nC1-INH (patients P11 and P12) went from 2.17 attacks per month to 0 attacks after 3 months of treatment (P11) and from 5.5 attacks per month to 2.0 attacks per month and reduced attack severity reported after 6 months of treatment (P12).