NLRP3 and type 2 diabetes mellitus: Thus, we tested the hypotheses that (1) Compared to subjects with low plasma apoB, subjects with high plasma apoB have higher WAT NLRP3 inflammasome activity indicated by higher WAT IL-1β secretion (primary), (2) WAT IL-1β secretion is associated with risk factors for T2D, and (3) native LDL prime and/or activate the NLRP3 inflammasome in subjects’ own WAT ex vivo.