While WAT NLRP3 and IL1B mRNA expressions were associated with all examined risk factors for T2D without apoB-group differences (Fig. 6B, Supplemental Figure 9), there was a dichotomy in the association of WAT IL-1β-secretion to these factors dependent on the WAT stimuli, IL-1β-secretion levels, and the study group. Here, IL1B is linked to type 2 diabetes mellitus.