COMMD4 and non-small cell lung carcinoma: Similar to COMMD4 depleted NSCLC cells, transfection of NSCLC cells with FLAG-H2BWT resulted in significantly more aberrant nuclei, indicative of mitotic catastrophe induction, relative to FLAG-H2BMUT1, mimicking COMMD4 siRNA depletion in these cells (Fig. 5a, b).