H460, H1299 and CRL5889 NSCLC cells transfected with FLAG-H2BWT, showed significantly increased early and late apoptosis compared to FLAG-H2BMUT1 and mock-transfected cells (Fig. 5c, d), with FLAG-H2BWT transfection mimicking COMMD4 siRNA depletion. Here, COMMD4 is linked to non-small cell lung carcinoma.