Since H2BWT bound to COMMD4 and inhibited the COMMD4-H2B interaction (Fig. 2), we next determined whether overexpression of this peptide in NSCLC and control human bronchial epithelial cells, HBEC3-KT, can mimic COMMD4 siRNA depletion. Here, COMMD4 is linked to non-small cell lung carcinoma.