Significant associations were identified between genetically proxied IL6R and IL1β mediated lower CRP levels and reduced risk of RA on primary IVW (IL6R: OR 0.57, 95% CI 0.39–0.82; IL1β: OR 0.49, 95% CI 0.30–0.79) and sensitivity analyses. This evidence concerns the gene CRP and rheumatoid arthritis.