We developed and showed that monosialoganglioside-containing nanoliposomes (NL, composed of 70% phosphatidylcholine, 25% cholesterol and 5% monosialoganglioside) reversed amyloid light chain- and medin-induced endothelial dysfunction and medin-induced endothelial cell pro-inflammatory activation in part by triggering nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant stress response and preventing NFκB activation4,9. The gene discussed is NFE2L2; the disease is endothelial dysfunction.