TP53 and melanoma: Established risk factors for malignant melanoma include ultraviolet radiation (UVA and UVB) from tanning beds, direct sun exposure, sunburns, dysplastic naevi, family history of melanoma, freckles, light hair and light skin4 In primary and malignant melanoma, p53 tumour-suppressing protein is expressed at high levels5,6 It has been suggested that p53 is not mutated in melanoma.