Over-representation analysis on the Reactome Pathway Database26 (Fig. 7) displayed 5 mitochondrial genes, MT-CO2, MT-CYB, MT-ND2, MT-ND6 and MT-TP, which play an important role in oxidative phosphorylation and respiratory electron transport chain reactions, processes which are affected in the lymphocytes of MM patients (Fig. 7b). Here, MT-ND2 is linked to Miyoshi myopathy.