Interestingly, MSH2 variant carriers carrying the AC genotype for rs1801131 had a significantly reduced risk of CRC, with a 26% reduction compared to those with the AA genotype (HR 0.74 (CI0.58–0.93), p = 0.010, see Table 4 and Fig. 2) but not those with the CC genotype. Here, MSH2 is linked to colorectal carcinoma.