MSH2 and cancer: Genotype distributions were consistent with Hardy–Weinberg equilibrium for A1298C (rs1801131) (p = 0.126) and C677T (rs1801133) (p = 0.099).The mean age of cancer onset in this sample population is 47 years (54 years for MSH6 and 44 years for both MLH1 and MSH2 variant carriers).