MSH2 and colorectal carcinoma: As expected, individuals with germline variants in MSH6 demonstrated a reduced risk of CRC (mean age of onset 54 years) compared to both MLH1 and MSH2 (both with a mean age of onset of 44 years) germline variant carriers (this is consistent with all genotypes for both SNPs in the current study), see Figs. 1 and 2.