lncRNA CRNDE, a molecular sponge of miR-181a-5p, is involved in regulating the expression of T cell factor 4 (TCF4)and β-catenin and regulates the proliferation and chemo-resistance in colorectal cancer by affecting the WNT/β-catenin signaling pathway [44]. The gene discussed is TCF7L2; the disease is colorectal cancer.