ACSS2 and congenital rubella syndrome: More importantly, the administration of a single dose of D-mannose markedly reduced the immobility of mice with CRS-induced depressive-like behaviors in the TST from 3 h posttreatment to 12 h and led to higher ACSS2, BDNF, and TPH2 levels, and these antidepressant effects disappeared until 24 h after treatment with acute D-mannose (Fig. 2K–N).