Consistent with these findings, specific ACSS2 downregulation in the hippocampus through stereotactic injection of a lentivirus carrying small interfering RNA targeting Acss2 also caused anxiety- and depressive-like behaviors in the OFT, EPM, TST, FST, and SPT (Fig. 1C, D, S1F, G). Here, ACSS2 is linked to Anxiety.