More importantly, the administration of a single dose of D-mannose markedly reduced the immobility of mice with CRS-induced depressive-like behaviors in the TST from 3 h posttreatment to 12 h and led to higher ACSS2, BDNF, and TPH2 levels, and these antidepressant effects disappeared until 24 h after treatment with acute D-mannose (Fig. 2K–N). The gene discussed is TPH2; the disease is congenital rubella syndrome.