TG and HDL-C have been considered surrogate insulin resistance in the diagnosis of MetS17,18, and their relationships with insulin resistance differ by ethnicity;18 WC may to a large extent indicate the deposition of excess fat in internal organs, which could increase MetS and CVD risks by disrupting hormone secretion, lowing the level of insulin, and elevate the level of blood fat19. Here, INS is linked to Insulin resistance.