Moreover, RNA-seq results showed that NAT10 promoted the transcription of multiple critical cytokines such as CXCL3 and CXCL8 and suppressed CXCL10, CXCL11 and so on, which are important for the recruitment of immune cells, angiogenesis, tumor microenvironment remodeling, and cancer progression. Here, NAT10 is linked to cancer.