However, our data reveal that Fbxw7-depletion in hepatocytes, via stimulating macrophage-mediated production and secretion of inflammatory mediators, activates hepatic stellate cells toward fibrogenesis and contributes to NASH progression, implying that Fbxw7 integrates the physiological and metabolic activities of different cell types in the liver. Here, FBXW7 is linked to metabolic dysfunction-associated steatohepatitis.