Moreover, we observed that 82% of DEGs (2834 of 3470) presented in Fbxw7-null livers were differentially bound by ERRα in comparison with control livers (FC ≥|1.5|), including genes involved in FAO (Cpt1a), autophagy (Bnip3, Atg7), lipoprotein metabolism (Apoa4), inflammation (Il1rn) and NASH progression (Col1a1, Fermt1, Epb41l4a), suggesting their reliance on an ERRα-dependent transcriptional network (Fig. 8g). Here, CPT1A is linked to metabolic dysfunction-associated steatohepatitis.