FBXW7 is of particular interest in the context of NASH as it is known to regulate the protein stability of key metabolic transcription factors including SREBP1/2, the nuclear receptors REV-ERBα (NR1D1) and ERRα (NR3B1) as well as the coregulator proteins NCOA3 and PGC-1α13–18. The gene discussed is NR1D1; the disease is metabolic dysfunction-associated steatohepatitis.