FBXW7 and metabolic dysfunction-associated steatohepatitis: GO cellular component analysis further demonstrated that these differentially expressed genes (DEGs) of NASH progression or Fbxw7-null livers were most enriched in “Collagen-containing extracellular matrix”, followed by “Basement membrane”, “Focal adhesion”, and “Endoplasmic reticulum lumen” (Supplementary Fig. 1j), in agreement with previous findings that NASH is accompanied by extracellular matrix (ECM) accumulation largely formed by type I collagens together with prolonged ER stress6,33,34.