In summary, since both functional and structural signs were observed in patients with the PRPH2 mutation p.Arg195Leu were also found in C57BL/6J-Prph2em1Sal mice, this animal model is the best approach to understanding the degenerative process of this retinal dystrophy and will permit us in the future to analyze the efficacy of different therapeutic approaches. The gene discussed is PRPH2; the disease is Retinal dystrophy.