In contrast to the lack of modulation of A2AR expression within the tumor by anti-PD-L1 therapy, a significant increase in the proportion and absolute number of tetramer+A2AR+ CD8+ T cells within the draining lymph nodes was observed, suggesting that these cells may be more susceptible to adenosine mediated immunosuppression post-treatment (Fig. 4G). Here, ADORA2A is linked to neoplasm.