Although we observed increases in A2AR expression in cDC2s and, to a lesser extent, cDC1s following immune checkpoint blockade, it was somewhat surprising that we did not observe increases in A2AR expression within tumor-infiltrating T cells following PD-L1 blockade or treatment with anti-CTLA-4 and anti-PD-L1. The gene discussed is ADORA2A; the disease is neoplasm.