Generation of CAR T cells led to increased expression of GFP relative to naïve T cells (Fig. 1H) and coculture of anti-Her2 CAR T cells with AT-3-, E0771-, or MC38-Her2 expressing tumor cells led to a further and significant induction of GFP in both CD8+ and CD4+ CAR T cells (Fig. 1I). The gene discussed is CD8A; the disease is neoplasm.