ADORA2A and neoplasm: To further interrogate the impact of immune checkpoint blockade on A2AR expression, and to investigate the possibility that A2AR was transiently upregulated following treatment, further experiments were performed to determine the expression of GFP on CD8+ tumor-infiltrating lymphocytes (TILs) at days 2 and days 4 post-treatment with either anti-PD-L1 or anti-PD-L1 and anti-CTLA-4.