Similarly, in the orthotopic HCC mouse model, the treatment with SnSNPs@PEG with NIR808 and US irradiation elevated the level of total CD45+ cells (Fig. S22a), CD45+CD3+ cells (Fig. S22b), CD45+CD3+CD4+ lymphocytes (Fig. S22c) and CD45+CD3+CD8+ CTL (Fig. S22d) by 2.0-fold, 5.4-fold, 3.2-fold and 7.1-fold, respectively. This evidence concerns the gene PTPRC and hepatocellular carcinoma.