In particular, we found that overexpression of Cacna2d1, one gene that encodes for the voltage-dependent calcium channel auxiliary subunit α2δ-1, was sufficient to rescue HFD-induced obesity and to restore the mIPSC frequency, as well as abnormal strengthened calcium signaling during eating on vlPAG GABAergic cells. The gene discussed is CACNA2D1; the disease is Obesity.