TNFRSF11B and type 1 diabetes mellitus: NOD/Ltj female mice with spontaneous recent-onset T1D (defined as blood glucose >250 mg/dl for three consecutive days) were treated with vehicle (daily) or different regimens of OPG (0.3 and 1.0 μg/g daily or 10.0 μg/g 2×/week) for 30 days (Fig. 6F).