TNFRSF11B and diabetes mellitus: Diabetes incidence, which was 100% at day 0 for the three groups, remained 100% in vehicle- and IgG-treated mice but dropped to 30% by day 40 in OPG-treated mice and was significantly reduced compared to vehicle- and IgG-treated groups (Fig. 7I) but was not significant compared to the control ND group.