Downregulation of FcγRIIb is further reported in non-alcoholic fatty liver disease in humans [82], and, interestingly, the authors also observed a significant negative correlation between FcγRIIb expression in liver tissue and high serum levels of blood lipids, type 4 collagen and hyaluronan in the patients [82]. The gene discussed is FCGR2B; the disease is metabolic dysfunction-associated steatotic liver disease.