Reduced FcγRIIb expression is reported in damaged LSECs in chronic liver inflammation and cirrhosis [12], and single-cell RNA sequencing of liver of mice with CCl4 induced liver fibrosis showed loss of Fcgr2b in the pericentral zone of the hepatic lobule, i.e. in the zone with most severe pathology [78]. The gene discussed is FCGR2B; the disease is Hepatic fibrosis.